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2 Overview of ferroptosis Ferroptosis, first identified in 2003 and formally named in 2012, is a distinct form of regulated cell death characterized by unique morphological, biochemical, and genetic features ( 2+ )-mediated Fenton reactions

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utilized male C57BL/6J mice to establish a liver fibrosis model, and the administration of pirfenidone indicated that it targets glutaredoxin-1 to suppress hematopoietic stem cell activation and liver fibrosis [57]

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