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Core mechanisms of mitochondrial metabolic reprogramming Supplying flexible fuel: metabolic plasticity and therapeutic resistance CRC cells exhibit pronounced metabolic plasticity, enabling dynamic switching between glycolysis and mitochondrial OXPHOS in response to fluctuations in oxygen, glucose, and other metabolic substrates, thereby adopting a hybrid metabolic phenotype [6]

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People with variants in the SLC22A5 gene (often referred to as carnitine transporter deficiency) which results in carnitine deficiency can have skeletal myopathy and/or cardiomyopathy [7]

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