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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure
Purity and dosing accuracy in commercially available capsule products are rarely verified by independent third-party testing, making formulation quality the single biggest practical variable
M., von Gise, A., Zhou, P., Hu, T., He, L., Wu, K
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