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Generally, inflammasomes consist of a NLR inflammatory monomer, an effector protein (procaspase-1), and an adapter protein (apoptosis-associated speck-like protein, ASC) [224]
In Brazil, millions of people are estimated to be affected, making health education essential for developing self-care and disease management skills
Severely obese patients may be good candidates as well
Given the lower cost and ease of administration of oral vitamin B 12 , this might be a reasonable choice for replacement in many patients
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