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STEP 1 (published in NEJM 2021) demonstrated that participants receiving semaglutide 2.4 mg experienced mean reductions in total cholesterol of approximately 5-7%, LDL-C reductions of 5-8%, and triglyceride reductions of 12-15% from baseline
It remains unclear to which extent these effects contribute to the favourable cardiovascular and renal outcomes of SGLT2 inhibitors
The randomized, controlled study recruited over 17,000 people with overweight or obesity and preexisting cardiovascular disease
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