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While these can reduce inflammation, they often bring difficult side effects: Weight gain, bloating, and bone loss Increased infection risk Fatigue and mood changes High long-term costs Because these drugs suppress the immune system instead of balancing it, flare-ups frequently return once treatment stops
Experiments indicate that PKA is the predominant and most physiologically relevant effector through which beta agonists cause bronchial smooth muscle relaxation (Morgan et al, 2014)
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