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22,23 In patients with a normal or low-normal serum vitamin B 12 level, complete blood count results demonstrating macrocytosis, or suspected clinical manifestations, a serum methylmalonic acid level is an appropriate next step 1,2,6,18 and is a more direct measure of vitamin B 12 's physiologic activity
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254 Moreover, H3K18la in astrocytes contributes to bilirubin encephalopathy by upregulating nucleotide-binding oligomerization domain 2 (NOD2) expression, which boosts downstream MAPK and NF-B signaling pathway activation, exacerbating astrocytic neuroinflammation and pyroptosis
Hermes-Uliana C, Panizzon CPDNB, Trevizan AR, Sehaber CC, Ramalho FV, Martins HA, et al
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