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Most researchers report sustained benefits lasting 4 to 6 months post-cycle, which is why cycles are typically repeated only two to three times annually
GSTs containing cysteine in the active site (DHARs, GSTLs, GSTZ1, GSTF7, and GSTU19) and one GST with the ability to form heterodimers with a previously mentioned one (GSTF10 with GSTF7) were proven to undergo S-glutathionylation (Dixon and Edwards, 2010)
Nevertheless, the current evidence remains largely inconclusive and does not demonstrate any clear benefit of a gluten-free diet (GFD) in patients without concomitant celiac disease, warranting further investigation [141,144,145,146,147,148,149]