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There is also a pill called Contrave, which combines buproprion and naltrexone and is FDA-approved for weight management, with weight loss of up to 8% after a year

A small but growing body of evidence has explored this question: Castaeda et al., 2025 ( Lancet Obstetrics, Gynaecology & Womens Health ) Postmenopausal women treated with tirzepatide who were also using menopausal hormone therapy lost approximately 35% more weight than non-users

A healthcare professional may recommend taking vitamin B12 supplements during pregnancy, particularly if a person is not getting enough vitamin B12 from their diet