It is not a drug manufacturer
The recording chamber, with a volume of 500 L, was continuously superfused at a rate of 12 mL/min

Am J Hypertens 14:694698 Mancia G, Kreutz R, Brunstrm M, Burnier M, Grassi G, Januszewicz A, Muiesan ML, Tsioufis K, Agabiti-Rosei E, Algharably EAE, Azizi M, Benetos A, Borghi C, Hitij JB, Cifkova R, Coca A, Cornelissen V, Cruickshank JK, Cunha PG, Danser AHJ, Pinho RM, Delles C, Dominiczak AF, Dorobantu M, Doumas M, Fernndez-Alfonso MS, Halimi JM, Jrai Z, Jelakovi B, Jordan J, Kuznetsova T, Laurent S, Lovic D, Lurbe E, Mahfoud F, Manolis A, Miglinas M, Narkiewicz K, Niiranen T, Palatini P, Parati G, Pathak A, Persu A, Polonia J, Redon J, Sarafidis P, Schmieder R, Spronck B, Stabouli S, Stergiou G, Taddei S, Thomopoulos C, Tomaszewski M, de Van Borne P, Wanner C, Weber T, Williams B, Zhang ZY, Kjeldsen SE (2023) 2023 ESH guidelines for the management of arterial hypertension the Task Force for the management of arterial hypertension of the European Society of Hypertension: endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)

When you dose 24 hours early, you're adding new medication to an existing therapeutic level rather than restarting from zero