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Daniels N, Moerkerke M, Steyaert J, et al
Summary first published in September 2012, authored by Peter Renner and Markus Horneber
In the Phase 2 retatrutide trial published in the New England Journal of Medicine (2023), participants at the highest dose (12 mg) achieved a mean body weight reduction of approximately 24.2% over 48 weeks
Our metabolic analyses showed that Gclc deficiency led to an accumulation of succinate, indicating a block in the TCA cycle
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