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A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

In active detox protocols under practitioner supervision, higher doses may be warranted

In short, giving B12 to special groups needs a careful plan

Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible