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I am going to generalize here, but many people who are taking these new GLP-1 weight loss meds are not going to exercise or monitor their diets

For women with lipoedema who already commonly present with digestive issues, histamine intolerance, MCAS, reflux associated with hiatus hernia, or who wear compression garments that fit around the abdomen, which can place upward pressure on the stomach, this cascade of gastrointestinal complications is a very real and underacknowledged risk that needs consideration before starting these medications

These effects were also observed when iron chelator was administered to pathogenic T cells, in addition to a downregulation of molecules involved in the glucose metabolism pathway, such as AKT, mTOR and PFKFB4, and of CD71 (36)

Therefore, compounds that are involved in the KYN pathway may play a key role in both the pathogenesis and treatment of mood disorders