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So, when these two are mixed, the fast a cid-base reaction occurs first, forming an ammonium salt, before any nucleophilic substitution reaction: Because of this, it is not practical to prepare an amide by direct reaction of a carboxylic acid and amines
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And the goal is not simply enhancement but restoration of balance
This method is particularly effective for people with vitamin B12 deficiency, which is common in older adults, vegetarians, and individuals with certain medical conditions
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