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20 Dipeptidyl-peptidase-4 inhibitors are less potent in terms of lowering A1C (0.5% to 0.9%) and more expensive compared with other generically available agents

Studies have shown that the NLRP3 inflammasome is also involved in other skin diseases, such as psoriasis, urticaria, and bullous pemphigoid (179)

The strongest clinical use cases are musculoskeletal injuries, gut lining integrity, and systemic inflammation

The dose is usually increased every 4 weeks until the maintenance dose is reached: Weeks 1 to 4: 0.25mg once weekly Weeks 5 to 8: 0.5mg once weekly Weeks 9 to 12: 1.0mg once weekly Weeks 13 to 16: 1.7mg once weekly Week 17 and onwards: 2.4mg once weekly (maintenance dose) Your treatment provider may adjust this schedule depending on how well you tolerate the medicine