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I had doled out the same recommendations to my own patients a million times, without much success
Ensure adequate calorie intake to prevent excessive muscle breakdown
The body defends against weight loss through mechanisms that increase hunger, reduce energy expenditure, and enhance nutrient absorption efficiency
Mechanistically, phenotypic heterogeneity may arise from factors such as uneven division of cells and their constituents, heterogeneous stages of the cell cycle or cell ageing, epigenetic modifications and stochastic gene expression [111314]
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