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Research published in Neuro Endocrinology Letters showed that ipamorelin stimulates insulin release from the pancreas, which is actually beneficial for glucose control

doi: 10.1093/cvr/cvaa271 Summary Keywords hyaluronidase, arginin-vasopressin, ADH, hypertension, Aquaporin 2, water metabolism, water load, blood pressure Citation Calvi A, Bongrani A, Verzicco I, Figus G, Vicini V, Coghi P, Montanari A and Cabassi A (2024) Urinary hyaluronidase activity is closely related to vasopressinergic system following an oral water load in men: a potential role in blood pressure regulation and early stages of hypertension development

Most of the clinical studies showing measurable effects ran for 4-6 months