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GLP-1-GIP co-agonist tirzepatide was approved by the US Food and Drug Administration in 2022 for the treatment of T2DM (Nogueiras et al., 2023)

Rybelsus is a once-daily oral tablet (3, 7, 14, or 25 mg) approved for type 2 diabetes, cardiovascular risk reduction, and obesity (obesity indication added December 2025)