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However, formation of glial scar via the accumulation of reactive astrocytes is a major obstacle to axonal regeneration by neurons after injuries ( Exogenous HGF treatment shows an anti-fibrotic activity in animal models, such as the tMCAO model, exerted through the decrease of glial scar formation and scar thickness of the brain pia matter ( Met -transgenic mouse was also generated, showing that the enhancement of MET levels in neurons selectively delays the disease onset in ALS mice models, prolonging lifespan, retarding motor neuron loss, and ameliorating motor performance ( HGF Induces Angiogenesis in the Nervous System The ischemic stroke caused by reduced blood supply to specific areas of the brain leads not only to neuronal death but also to endothelial cell damage, which can result in the disruption of the BBB