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ZA and DJM are principal investigators and made contributions to the design of the study, acquisition (DJM) and interpretation of the data, and revision of the manuscript

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1 Introduction The advent of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their combinations, as pharmacological treatments for obesity and type 2 diabetes, has sparked intense debate about their role relative to traditional lifestyle interventions such as exercise and dietary modification

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Weight loss is rarely linear, and plateaus are common and normal during treatment

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