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The other two PAF-AH enzymes, namely Group VIIB and VIII, are intracellular (Table 2)
When colorectal cancer patients with liver metastases took 3.6 g/day of curcumin orally for seven days, trace levels of curcumin metabolites were measured in liver tissue, but curcumin itself was not detected (11)
Target Concerns: - Heart health
the principal pharmacological-interaction consideration is co-administration with exogenous melatonin or other pineal-axis-modifying agents, where the proposed mechanism overlaps and pharmacodynamic addition rather than subtraction would be expected
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