does semaglutide cause birth defects Millions of women of reproductive age are now taking GLP-1 medications like and liraglutide for diabetes and weight management. A new systematic review in JACC: Advances asks an increasingly important question — Ozempic Pregnancy Effects and Risks

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Liver energy metabolism reprogramming: GLP-1RA reduces hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting liver sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"