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It is noteworthy that these subsets have significant differences in their sensitivity to oxidative stress: B1 and MZ B cells have high expression of key enzymes involved in lipid synthesis, such as acetyl-coenzyme A carboxylase (ACC) and fatty acid synthase (FASN), resulting in elevated levels of ROS in the cells, and are therefore highly dependent on GPX4 to maintain redox homeostasis (158)

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Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

By connecting metabolic signatures with pH dynamics, metabolomics supports quality control while deepening insights into how diet, genetics, handling and storage influence fish muscle shelf life and quality [120, 121]