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A recent retrospective cohort also observed that, even in overweight patients without diabetes, the risk of primary open-angle glaucoma and ocular hypertension were significantly lower in the GLP-1RA group at both 3 and 5 years of follow-up (Vasu et al., 2025), suggesting the benefit of GLP-1RAs in the eye as an independent factor apart from blood glucose control

(That explains why its given on a once-weekly schedule)

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Side effects and tolerability Like other medications in the incretin class, retatrutide caused gastrointestinal side effects in some patients