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Patient-reported outcome results in patients with type 2 diabetes treated with once-weekly dulaglutide: data from the AWARD phase III clinical trial programme
A central function of ERAD is the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol biosynthesis
doi: 10.1677/jme.0.0100259 48 LupiRDel GuerraSDAleoVBoggiUFilipponiFMarchettiP
Semaglutide can attenuate inflammation in MASLD by downregulating the IRE1-XBP1-C/EBP (inositol-requiring transmembrane kinase/endonuclease-1-X-box binding protein 1-CCAAT/enhancer binding protein ) pathway in macrophages ( 2 ( 4.1.2 GLP-1RAs regulate the immune cells to protect the liver against fibrosis and neoplasia Exenatide and liraglutide can elevate cAMP levels and reduce the M1/M2 ratio through the cAMP-PKA-STAT3 pathway, resulting in amelioration of injured liver function and liver inflammation (Somm et al., 2021)
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