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Increasing evidence indicates that PSC activation plays an important role in the progression of islet fibrosis in T2DM patients and animal models [7, 33, 34]

The reduction of dehydroascorbate may be non-enzymatic or catalysed by proteins with dehydroascorbate reductase activity, such as glutathione S -transferase omega 1 or glutaredoxins

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(PDF 2629 kb) Human blood was processed for GSH analysis by HPLC (i.e., by collection into tubes containing K 3 EDTA/NEM310 and deproteination by addition of TCA15 (as described in the PROCEDURE))