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Tools such as CRISPR/Cas9 and single-cell epigenomics have identified precise targets (e.g., ESR1, PTEN, PD-L1), revealing mechanisms such as PTEN loss, CDK4/6 upregulation, and PD-L1 regulation [237,238]
& Khan, S
BPC-157 and TB-500 subsequently emerged as recognised research compounds due to their defined structures, reproducible analytical characteristics and suitability for controlled experimental investigations
Studies examining asthma, COPD and CF have focused on the role of the immune system [3,4,5,6,7] and epithelial ion channels in mucus secretion [8,9,10,11,12], but the involvement of the nervous system, and in particular neuropeptide signaling, remains a field of much unknowns [13]
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