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zeta potential 51.3 mV) are not considered optimal for BBB permeability according to current nanoneuroscience literature (Hong et al
PMID: 29 AbrahamEJLeechCALinJCZulewskiHHabenerJF
Instead, GIP co-activation seems to buffer some of the harsher GLP-1 effects
For example, Sitagliptin was shown to increase GLP-1 and GLP-1 receptor expression in spontaneously hypertensive rat renal arteries by Liu [130]
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