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That scale means even an unexpected benefit, or an unexpected harm, becomes a public health event
Patients (76% males, 89% Caucasian, 93% enrolled at US sites, 89% with a history of angina, 52% without PCI, 4% with PCI and no stent, and 44% with a stent) were randomized to double-blind treatment with either amlodipine besylate (5 to 10 mg once daily) or placebo in addition to standard care that included aspirin (89%), statins (83%), beta-blockers (74%), nitroglycerin (50%), anti-coagulants (40%), and diuretics (32%), but excluded other calcium channel blockers
Additional trials for tirzepatide will include its effect in people who have non-alcoholic fatty liver disease and congestive heart failure
When to Be Concerned While many period changes are normal during weight loss, there are times to check in with a provider: Youve missed three or more periods in a row Your bleeding is unusually heavy or painful You experience spotting for more than a few days between periods You think you might be pregnant You have a history of hormone imbalance or reproductive health issues Remember: GLP-1s are powerful, but theyre not one-size-fits-all
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