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Nature 372 , 425432 (1994)
The compound was active at very low doses and showed oral bioavailability, crossing the blood-brain barrier after systemic administration
The peptide is not classified as a GH secretagogue and does not appear to significantly elevate systemic IGF-1 levels, which remains an important distinction for clinicians evaluating tissue repair pathways
It also stimulates the production of proteoglycans (decorin, biglycan) and glycosaminoglycans, which contribute to hydration and elasticity of the dermis
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