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The mechanisms are complex.chronic low-grade inflammation, insulin resistance, hormonal dysregulation, mechanical stress on joints
A real-world study followed individuals who started GLP-1 medications and discontinued them within 3 to 12 months to assess weight changes after stopping treatment
Cell 184 (8): 1945-1948
Procedures such as sleeve gastrectomy or Roux-en-Y gastric bypass produce substantial, durable weight loss through both mechanical and hormonal mechanisms, including increased endogenous GLP-1 production
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