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Serotonin Syndrome Counteraction A 2005 study in the European Journal of Pharmacology (PMID: 15840402) induced severe serotonin syndrome using pargyline (MAO inhibitor) plus L-tryptophan (serotonin precursor), producing forepaw treading, hindlimb abduction, wet dog shake, and hyperthermia mediated primarily through 5-HT2A receptors

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Glycemic and metabolic markers: Trial disclosures describe improvements in glycemic control and cardiometabolic measures alongside weight loss, with cardiovascular outcomes still under study in REDEFINE 3 [8]