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In a more complex murine CRC model, we used orthotopic endoscopy-guided submucosal injection 24,25,26 of 4-hydroxytamoxifen to drive allelic recombination in AKP mice and promote tumour formation
[9] [10] It works through multiple mechanisms: stimulating insulin secretion when blood glucose levels rise, suppressing glucagon release, slowing gastric emptying, and reducing appetite through effects on the brain
This can represent a substantial portion of the calorie deficit needed for weight loss
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