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Additionally, semaglutide slows gastric emptying, prolonging the sensation of fullness and reducing the frequency of hunger signals

Note: These findings are derived from animal and in vitro models

Important red flags that require immediate medical attention include: Severe, persistent abdominal pain (possibly radiating to the back) with or without vomiting, which may suggest acute pancreatitis Right upper quadrant pain, fever, or yellowing of the skin/eyes, which could indicate gallbladder disease Reduced urine output or marked dehydration from persistent gastrointestinal symptoms Sudden changes in vision, particularly in those with diabetic retinopathy Cardiovascular symptoms such as palpitations, chest discomfort, or lightheadedness should prompt immediate medical review

1,16 One advantage to using sulfonylureas as add-on therapy to metformin is cost