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The signal for acute kidney injury (675 cases) was more prominent in elderly and overweight groups, potentially linked to metformins contraindication in renal impairment 34 and the dehydration effects of GLP-1RAs 40 , highlighting the need for strict baseline renal function screening and monitoring of blood volume status
Some patients use the programme for a 3-4 months, while others may remain on treatment for longer periods, 6-8 months, depending on their goals and medical needs
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