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Start your intake Why Weight Gain Occurs During Semaglutide Treatment Weight gain on semaglutide typically happens in three scenarios: during dose escalation phases when appetite suppression hasn't fully kicked in, after stopping the medication when metabolic rate normalizes, or due to compensatory eating when users misunderstand dosing schedules
In fact, the goal of GLP-1 use is to focus on physical health, mental health and well-being, rather than body weight alone (Mozafarriun et al 2025)
With this insight, you and your provider can design a personalized maintenance planwhether that means continuing tirzepatide, switching to semaglutide, or combining medication with intensive behavioral support
2C) were both increased by Exendin-4 pre-conditioning
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