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ipamorelin, GHRP-6) that act through the ghrelin/GHS-R pathway, tesamorelin operates upstream through the native GHRH axis, preserving the physiological pulsatility of GH secretion observed in cellular and preclinical research models

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J Biol Chem 264:1351913523 Vojdani A, Mumper E, Granpeesheh D, Mielke L, Traver D, Bock K, Hirani K, Neubrander J, Woeller KN, OHara N, Usman A, Schneider C, Hebroni F, Berookhim J, McCandless J (2008) Low natural killer cell cytotoxic activity in autism: the role of glutathione, IL-2 and IL-15