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doi:10.1001/jama.2020.18977

In addition, animal, observational, and genetic studies suggest benefits of GLP-1RAs in people with alcohol use disorder, although randomized trials have produced mixed results, with ongoing trials assessing their effectiveness in those with substance use disorders (SUDs) and mental illnesses

Daniel Drucker's 2018 synthesis of GLP-1 pharmacology in Cell Metabolism lays out the four core actions that make the hormone useful: it stimulates glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and acts centrally to enhance satiety (Drucker, 2018)

FDA-approved products like Ozempic, Wegovy, Mounjaro, and Zepbound have undergone extensive premarket review