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In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)

Brain function and mood B12 is crucial for healthy nerve function and neurotransmitter production, impacting memory, focus, and mood

However, its most critical role in this context is how it interacts with glutathione

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