While we used several markers (including SA--gal, lipofuscin, cyclin-dependent kinase inhibitors, SASP components and transcriptional senescence signatures) to characterize senescence in these models, we have to acknowledge the limitations of our study given the inherent heterogeneity of senescent cells
Still, it may progress into more severe forms of liver disease, such as nonalcoholic steatohepatitis (NASH) or cirrhosis, if not addressed, both of which can lead to permanent damage and reduced liver function
Animal models show reduced osteoarthritis progression and improved cartilage quality
Thats why we combed Reddit to find out what people are currently talking about in obesity and GLP-1 communities and asked the following medical experts to respond to readers most pressing questions: Kia Mitchell, MD Double board-certified family and obesity medicine physician and founder of the International Womens Obesity Network Marsha Novick, MD, FAAFP Spokesperson for The Obesity Society and board member of the American Board of Obesity Medicine Richele Corrado, DO, MPH Spokesperson for The Obesity Society and medical director, internist, and obesity medicine physician at Revolution Medicine, Health & Fitness Sherrie Singh-Bryan, PharmD, CDCES Clinical pharmacist and certified diabetic care and education specialist at Winn Army Community Hospital in Fort Stewart, Georgia Editors note: These interviews have been edited for length and clarity