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Elevated IGF-1 levels are associated with increased cancer risk in observational studies, particularly for hormone-sensitive tumors. Pollak, Nature Reviews Cancer Avoid use if you have: Personal or family history of cancer Undiagnosed growths or polyps A genetic predisposition to hormone-related cancers Diabetics and Individuals with Insulin Resistance IGF-1 directly affects glucose uptake and insulin signaling

Schimmer AD, O'Brien S, Kantarjian H, Brandwein J, Cheson BD, Minden MD, Yee K, Ravandi F, Giles F, Schuh A, Gupta V, Andreeff M , Koller C, Chang H, Kamel-Reid S, Berger M, Viallet J, Borthakur G

This guide will help you navigate the key factors to consider, such as dosage (typically around 500 mg to 4,000 mg per day), benefits, and potential side effects, so you can choose a supplement that aligns with your specific needs

High-dose intravenous vitamin C holds the second position in this ranking because its evidence base is simultaneously among the broadest and most mechanistically precise of any longevity IV intervention