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TRPV1 Channel Inhibition: Research published in Molecular Immunology (2023) identified a second direct analgesic mechanism ARA-290 specifically inhibits TRPV1 (Transient Receptor Potential Vanilloid 1) channel activity in peripheral nociceptors, increasing the pain threshold and relieving mechanical hypersensitivity independent of its anti-inflammatory IRR actions
The peptide stimulates expression of early growth response 1 (EGR-1) gene, which regulates cytokine and growth factor generation along with early extracellular matrix formation, while simultaneously inducing its repressor NAB2 to prevent excessive angiogenic signaling
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