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Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH
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In each set, the time course is followed by the change from baseline (mean of days 3 to 1) to the mean of days 1-3, 7-9, and 18-20, as indicated
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