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They used DPP4-targeted immune therapy by vaccines in a C57BL/6J mouse model and were able to show comparable effects like in treatments with gliptins regarding GLP-1 plasma levels and post-prandial glucose excursion and insulin sensitivity in HFD-fed mice
Ghrelin is also produced in the central nervous system, including the hypothalamus and pituitary gland, although levels in these tissues are minimal
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Researchers at the Institute of Metabolic Science, University of Cambridge, have been exploring whether this hormone might also underlie chronic diarrhea in humans
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