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The zonula occludens (ZO) protein family, a group of membrane-associated guanylate kinase tight junctions, plays a central role in scaffold protein binding to the cytoskeleton [50]

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A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer