leading semaglutide class action Contractile Effects of in the Human Atrium Semaglutide (Ozempic, Wegovy, Rybelsus) -

Semaglutide escalates in uneven steps (0.25, 0.5, 1.0, 1.7, 2.4 mg) while tirzepatide increases in uniform 2.5 mg increments (2.5, 5.0, 7.5, 10.0, 12.5, 15.0 mg)

Analysis showed that the trial met its primary endpoint of achieving a superior mean percent change in body weight with tirzepatide versus placebo from week 36 to week 88, with patients sustaining weight loss

Diabetes 64(3):715717 Aldawsari M, Almadani FA, Almuhammadi N, Algabsani S, Alamro Y, Aldhwayan M (2023) The efficacy of GLP-1 analogues on appetite parameters, gastric emptying, food preference and taste among adults with obesity: systematic review of randomized controlled trials

In other words, combining the two substances can make appetite changes and GI side effects harder to predict and potentially more uncomfortable