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This highlights the need for further research to distinguish between the risk of developing an autoimmune phenotype and the risk of progressing to severe clinical manifestations like TED. While the research teams findings suggest a protective association between GLP-1 drug therapy and TED, the underlying biological pathways remain speculative
doi: 10.3390/cancers11081086 116 YanTYanNWangPXiaYHaoHWangGet al
By engaging all three receptors concurrently, the drug is hypothesised to produce additive or synergistic effects on appetite suppression, insulin secretion, and energy expenditure though this remains to be confirmed in ongoing phase 3 trials
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