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Future efforts should focus on second/third generation highly selective RIPK1/3 inhibitors, combined with COPD-specific pharmacokinetic and safety evaluations, to truly answer whether necroptosis inhibition has an acceptable risk-benefit ratio. In terms of targeting pyroptosis/GSDMD, Disulfiram, a classic alcohol deterrent, has recently been found to covalently modify the key cysteine residue of GSDMD, blocking the insertion of the GSDMD-N terminal into membranes to form pores, thereby inhibiting pyroptosis and the release of IL-1 and IL-18 (263, 264)

When we look at specific goals like skin health, eye protection, or brain function, other compounds like astaxanthin or melatonin may actually offer higher levels of antioxidant activity in certain environments

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