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However, typical levels drop by more than half by age 60

Importantly, iron accumulation within microglia drives them toward a pro-inflammatory M1 state, which not only exacerbates neuroinflammation and DA neuronal loss but also establishes a vicious cycle involving inflammasome activation and ferroptosis (Yu et al., 2023)

Mitochondrial Longevity Mitochondrial GSH (mGSH) is independently regulated from cytosolic pools and is the primary defence against mitochondrial lipid peroxidation and protein oxidation