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UK Regulatory Position on GLP-1 Medicines and Cancer The Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA) maintain active surveillance of GLP-1 receptor agonists and have issued clear guidance regarding their safety profile, including cancer-related considerations

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Trial design: 751 adults with obesity (BMI 30, or 27 with at least one comorbidity) No type 2 diabetes 72-week follow-up Tirzepatide 10mg or 15mg vs Semaglutide 2.4mg Results at 72 weeks: When looking at tirzepatide weight loss results from SURMOUNT-5 alongside semaglutide weight loss results from the STEP trials, the gap is consistent and statistically significant across every subgroup sex, age, baseline BMI, and presence of metabolic comorbidities

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